Propiconazole induces alterations in the hepatic metabolome of mice: relevance to propiconazole-induced hepatocarcinogenesis.

@article{Nesnow2011PropiconazoleIA,
  title={Propiconazole induces alterations in the hepatic metabolome of mice: relevance to propiconazole-induced hepatocarcinogenesis.},
  author={Stephen Nesnow and William T Padgett and T. H. M. Moore},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={120 2},
  pages={297-309}
}
Propiconazole is a mouse hepatotumorigenic fungicide and has been the subject of recent investigations into its carcinogenic mechanism of action. The goals of this study were (1) to identify metabolomic changes induced in the liver by increasing doses of propiconazole in mice, (2) to interpret these results with key previously reported biochemical, transcriptomic, and proteomic findings obtained from mouse liver under the same treatment conditions, and (3) to relate these alterations to those… CONTINUE READING