Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.

@article{Nadelman2001ProphylaxisWS,
  title={Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.},
  author={Robert B. Nadelman and Jacek Nowakowski and David Fish and Richard C. Falco and Katherine B Freeman and Donna McKenna and Pam Welch and Ralph T Marcus and M E Ag{\"u}ero-Rosenfeld and David T. Dennis and Gary P. Wormser},
  journal={The New England journal of medicine},
  year={2001},
  volume={345 2},
  pages={79-84}
}
BACKGROUND It is unclear whether antimicrobial treatment after an Ixodes scapularis tick bite will prevent Lyme disease. METHODS In an area of New York where Lyme disease is hyperendemic we conducted a randomized, double-blind, placebo-controlled trial of treatment with a single 200-mg dose of doxycycline in 482 subjects who had removed attached I. scapularis ticks from their bodies within the previous 72 hours. At base line, three weeks, and six weeks, subjects were interviewed and examined… CONTINUE READING
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