Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.

  title={Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.},
  author={Marilyn J Manco-Johnson and Thomas C. Abshire and Amy D Shapiro and Brenda K Riske and Michele R. Hacker and Ray Kilcoyne and James D. Ingram and Michael L. Manco-Johnson and S. A. Funk and Linda Jacobson and L A Valentino and William Keith Hoots and George R. Buchanan and Donna M Dimichele and Michael P. Recht and Deborah Godfrey Brown and Cindy Anne Leissinger and Shirley Bleak and Alan C Cohen and Prasad Mathew and Alison Matsunaga and Desiree Medeiros and Diane Nugent and Gregory A Thomas and Alexis A Thompson and Kevin P McRedmond and J M Soucie and Harlan Austin and Bruce L. Evatt},
  journal={The New England journal of medicine},
  volume={357 6},
BACKGROUND Effective ways to prevent arthropathy in severe hemophilia are unknown. METHODS We randomly assigned young boys with severe hemophilia A to regular infusions of recombinant factor VIII (prophylaxis) or to an enhanced episodic infusion schedule of at least three doses totaling a minimum of 80 IU of factor VIII per kilogram of body weight at the time of a joint hemorrhage. The primary outcome was the incidence of bone or cartilage damage as detected in index joints (ankles, knees… CONTINUE READING
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Natural history of inhibitor development in children with severe hemophilia A treated with factor VIII products

  • JM Lusher
  • Haemophilia
  • 2007

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