Prophylaxis of migraine headaches with riboflavin: A systematic review

@article{Thompson2017ProphylaxisOM,
  title={Prophylaxis of migraine headaches with riboflavin: A systematic review},
  author={D. F. Thompson and Harjindrapal Sing Saluja},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={2017},
  volume={42},
  pages={394 - 403}
}
Migraine headache is a relatively common, debilitating condition that costs our healthcare system over 78 billion dollars per year. Riboflavin has been advocated as a safe, effective prophylactic therapy for the prevention of migraines. The purpose of this study was to provide a systematic review of the current role of riboflavin in the prophylaxis of migraine headache. 
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In adults, riboflavin at a dose of up to 400 mg daily reduces migraine frequency by more than 50% and is similar in efficacy to sodium valproate and propranolol, with significantly fewer side effects
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come measures, and short study durations. A 2012 Canadian Headache Society guideline addressed treatment options for migraine prophylaxis in adults. The authors strongly recommended (based on balance
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