Prophylaxis of implant-related staphylococcal infections using tobramycin-containing bone cement.

@article{Nijhof2000ProphylaxisOI,
  title={Prophylaxis of implant-related staphylococcal infections using tobramycin-containing bone cement.},
  author={Marc W. Nijhof and Wouter J. A. Dhert and Andr{\'e} Fleer and Henri C Vogely and Abraham J. Verbout},
  journal={Journal of biomedical materials research},
  year={2000},
  volume={52 4},
  pages={754-61}
}
In a rabbit model, premixed tobramycin-containing bone cement was studied for its efficacy to prevent infections with two frequently encountered staphylococcal species in arthroplasty surgery. After intramedullary inoculation with staphylococci, either standard or premixed tobramycin-containing Simplex-P bone cement was injected in the right femur of 120 rabbits. Development of infection was examined by culture of femoral bone after 7 or 28 days. Loss of body weight and elevated erythrocyte… CONTINUE READING

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