Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial.

@article{Brueckner1998ProphylaxisOP,
  title={Prophylaxis of Plasmodium falciparum infection in a human challenge model with WR 238605, a new 8-aminoquinoline antimalarial.},
  author={Ralf P. Brueckner and Trinka S. Coster and David L Wesche and M J Shmuklarsky and Brian G. Schuster},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 5},
  pages={1293-4}
}
The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria. 

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