Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus.

@article{Doyle1973ProphylaxisAI,
  title={Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus.},
  author={Michael Doyle and John J. Holland},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1973},
  volume={70 7},
  pages={2105-8}
}
Defective interfering T particles of vesicular stomatitis virus provide remarkable protection against viral disease and death when introduced intracerebrally in large numbers along with an otherwise rapidly fatal low dose of standard infectious virus. This profound prophylactic effect of defective T particles is due to homologous autointerference since it is serotype-specific and interferon is not induced. This protective effect can be demonstrated only with preparations of T particles that… CONTINUE READING

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