Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice.

@article{Ashani1991ProphylaxisAO,
  title={Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice.},
  author={Yacov Ashani and Nili Rothschild and Yoffi Segall and Dan Levanon and Lily Raveh},
  journal={Life sciences},
  year={1991},
  volume={49 5},
  pages={
          367-74
        }
}
Parathion hydrolase purified from Pseudomonas sp. was injected i.v. into mice to demonstrate the feasibility of using organophosphorus acid anhydride (OPA) hydrolases as pretreatment against organophosphates (OP) poisoning. Results show that exogenous administration of as low as 7 to 26 micrograms of parathion hydrolase conferred protection against challenge with multiple median lethal doses (LD50) of diethyl p-nitrophenyl phosphate (paraoxon; 3.8-7.3 x LD50) and diethylfluorophosphate (DEFP; 2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…