Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study.

  title={Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study.},
  author={Louis L M van de Ven and Cees L. Franke and Peter K{\"o}hler},
  journal={Cephalalgia : an international journal of headache},
  volume={17 5},
The objective of the present study was to assess the efficacy of bisoprolol in migraine prophylaxis. A double-blind placebo-controlled study was conducted in 226 patients with migraine with or without aura, a migraine history of at least 2 years at least 3 documented attacks during the 28 days run-in period. The duration of treatment was 12 weeks following an initial 28 days' run-in period. Patients reported the number of attacks and their severity in a diary. Treatment with bisoprolol 5 mg… CONTINUE READING

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