Prophylactic treatment of migraine with and without aura with acetyl-dl-leucine: a case series

@article{Strupp2018ProphylacticTO,
  title={Prophylactic treatment of migraine with and without aura with acetyl-dl-leucine: a case series},
  author={Michael Strupp and Otmar Bayer and Katharina Feil and Andreas Straube},
  journal={Journal of Neurology},
  year={2018},
  volume={266},
  pages={525-529}
}
The prophylactic treatment of migraine is still challenging, not only because of the effectiveness of drugs given but also because of their side effects which result in a low therapy adherence [4. [...] Key Method In a prospective observational case series, ten patients (six females, age range 18–70 years, Table 1) were treated on an individual basis with acetyl-dl-leucine during a period from 01/2017 to 09/2018.Expand
Effects of N-Acetyl-Leucine and its enantiomers in Niemann-Pick disease type C cells
TLDR
It is suggested that N-Acetyl-L-Leucine is the most effective enantiomer in correcting relative lysosomal volume in non-neuronal NPC cells, and support further research and development of the L-enantiomer. Expand
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance
TLDR
The results suggest that during chronic administration of the racemate, the D-enantiomer would accumulate, which could have negative effects, and support the research and development of only N-acetyl-L-leucine. Expand
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance
TLDR
The enantiomers of N-acetyl-leucine exhibit large, unexpected differences in pharmacokinetics due to both unique handling and/or inhibition of uptake and metabolism of the L-enantiomer by the D- enantiomer. Expand
N-Acetyl-l-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice
TLDR
It is demonstrated that orally administered N-acetyl-l-leucine (NALL) significantly improved motor and cognitive outcomes in the injured mice, led to the attenuation of cell death, and reduced the expression of neuroinflammatory markers after controlled cortical impact (CCI) induced experimental TBI in mice. Expand
Acetylation turns leucine into a drug by membrane transporter switching.
TLDR
It is shown that acetylation of leucine switches its uptake into cells from the L-type amino acid transporter used byLeucine to organic anion transporters (OAT1 and OAT3) and the monocarboxylate transporter type 1 (MCT1). Expand
Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)
TLDR
Examination of N-acetyl-L-leucine uptake in human embryonic kidney cells overexpression candidate organic anion transporters (OAT) and pharmacological inhibitors and results demonstrate a mechanism of action that explains why the analogue of the alpha amino acid leucine is effective as a drug and L-Leucine itself is not. Expand
30 Sent bioarchive
  • 2019

References

SHOWING 1-8 OF 8 REFERENCES
Effects of acetyl-dl-leucine in patients with cerebellar ataxia: a case series
TLDR
In conclusion, acetyl-dl-leucine significantly improved ataxic symptoms without side effects and therefore showed a good risk–benefit profile. Expand
Acetyl-dl-leucine in Niemann-Pick type C
TLDR
Treatment with AL improved ataxic symptoms in patients with NP-C without relevant side effects, thus showing a reasonable risk-benefit profile, and Class IV evidence that AL improves cerebellar symptoms and quality of life in patientswith NP- C. Expand
Adherence to oral migraine-preventive medications among patients with chronic migraine
TLDR
Adherence to OMPMs is low among the US CM population at six months and worsens by 12 months, and except for amitriptylines, nortriptyline, gabapentin, and divalproex, which had significantly lower odds of adherence when compared to topiramate. Expand
In vitro effects of acetyl‐dl‐leucine (tanganil®) on central vestibular neurons and vestibulo‐ocular networks of the guinea‐pig
TLDR
The results suggest that acetyl‐dl‐leucine might act mainly on abnormally hyperpolarized and/or depolarized MVN neurons, by bringing back their membrane potential towards a mean value of −65 to −60 mV. Expand
The International Classification of Headache Disorders
TLDR
The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed. Expand
A Systems Neuroscience Approach to Migraine
TLDR
This work conceptualize migraine as a disorder of sensory network gain and plasticity, and it is proposed that this framing makes it amenable to the tools of current systems neuroscience. Expand
Vestibular migraine: diagnostic criteria.
TLDR
Diagnostic criteria for vestibular migraine are presented, jointly formulated by the Committee for Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society, and will appear in an appendix of the third edition of the ICHD. Expand
tibular migraine : diagnostic criteria
  • J Vestib Res
  • 2012