Prophylactic sclerotherapy before the first episode of variceal hemorrhage in patients with cirrhosis.

@article{Sauerbruch1988ProphylacticSB,
  title={Prophylactic sclerotherapy before the first episode of variceal hemorrhage in patients with cirrhosis.},
  author={Tilman Sauerbruch and R Wotzka and Wolfgang Koepcke and Mikael S. H{\"a}rlin and Walter Heldwein and Ekkehard Bayerdoerffer and Ronald C. Sander and H. Ansari and I. Starz and Gustav Paumgartner},
  journal={The New England journal of medicine},
  year={1988},
  volume={319 1},
  pages={8-15}
}
The value of sclerotherapy as prophylaxis against the first episode of variceal hemorrhage has not been established. Therefore, we randomly assigned 133 patients with cirrhosis of the liver (of alcoholic origin in 66 percent), esophageal varices, and no previous intestinal bleeding to either prophylactic sclerotherapy (n = 68) or no prophylaxis (n = 65). The groups were comparable in hepatic function, endoscopic findings, and the pathogenesis of cirrhosis. All patients who subsequently had a… CONTINUE READING
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