Prophylactic oophorectomy in BRCA1/2 carriers.


1012 Background: Women who carry a BRCA1 or BRCA2 mutation are at increased risk for breast and ovarian cancer. Bilateral prophylactic oophorectomy (BPO) has been shown to decrease the risk of ovarian cancer by 85-96%, and the risk of breast cancer by 50%. Therefore, for mutation carriers, prophylactic oophorectomy is recommended after completion of… (More)