Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats.

@article{Lu2015ProphylacticLA,
  title={Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal TLR4 activation in aged rats.},
  author={Shun-Mei Lu and Bo Gui and Hong-Quan Dong and Xiang Zhang and Su-Su Zhang and Liu-Qing Hu and Hai-Ling Liu and Jie Sun and Yian-Ning Qian},
  journal={Brain research bulletin},
  year={2015},
  volume={114},
  pages={31-41}
}
Though the pathogenesis of postoperative cognitive dysfunction (POCD) remains unclear, evidence is accumulating for a pivotal role of neuroinflammation in the disease process. Advanced age and severe surgical trauma are two main risk factors for POCD. Lithium, a neuroprotective agent, can alleviate peripheral surgery-induced memory impairment in aged rats. The results of in vivo and in vitro experiments also showed that toll like receptor 4 (TLR4) was associated with the occurrence and… CONTINUE READING

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