Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma.

@article{Tomita2002ProphylacticIM,
  title={Prophylactic intrathecal methotrexate and hydrocortisone reduces central nervous system recurrence and improves survival in aggressive non-hodgkin lymphoma.},
  author={Naoto Tomita and Fumio Kodama and Heiwa Kanamori and Shigeki Motomura and Yoshiaki I Ishigatsubo},
  journal={Cancer},
  year={2002},
  volume={95 3},
  pages={576-80}
}
BACKGROUND Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS We retrospectively analyzed a cohort of 68 adults with NHL who had been treated uniformly with systemic chemotherapy and had attained complete remission (CR) of disease. Patients ranged in age from 15 to 77… CONTINUE READING

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