Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine.

@article{Cox1976ProphylacticIO,
  title={Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine.},
  author={James Hilton Cox and Leander Schneider},
  journal={Journal of clinical microbiology},
  year={1976},
  volume={3 2},
  pages={96-101}
}
The antirabies human diploid cell vaccine produced by 1'Institute Merieux, Lyon, France, was administered intradermally to 35 high-risk volunteers using 0.2-ml amounts and various immunization schedules. Three groups never before vaccinated against rabies developed virus-neutralizing antibodies, the titer of which was dose dependent. A single injection stimulated the formation of antibodies. Four inoculations induced the highest antibody levels and the longest persistence of antibody. The… CONTINUE READING

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