Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.

@article{Karlsson2009ProphylacticFI,
  title={Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.},
  author={Martin Karlsson and Lisa Ternstr{\"o}m and Monica Hyllner and Fariba Baghaei and Agneta W Flinck and Stanko Skrtic and A Jeppsson},
  journal={Thrombosis and haemostasis},
  year={2009},
  volume={102 1},
  pages={137-44}
}
It has been suggested that preoperative fibrinogen plasma concentration is independently associated to postoperative blood loss after cardiac surgery. Theoretically, prophylactic infusion of fibrinogen concentrate may thus reduce postoperative bleeding, but this has not previously been investigated. Twenty elective coronary artery bypass graft (CABG) patients with preoperative plasma fibrinogen levels <3.8 g/l were included in a prospective randomised pilot study. Patients were randomised to… CONTINUE READING
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