Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution.

@article{Suzuki2008ProphylacticEO,
  title={Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution.},
  author={Takahiro Suzuki and Norimasa Yoshida and Nami Nakabe and Yutaka Isozaki and Hirokazu Kajikawa and Tomohisa Takagi and Osamu Handa and Satoshi Kokura and Hiroshi Ichikawa and Yuji Naito and Hirofumi Matsui and Toshikazu Yoshikawa},
  journal={Journal of pharmacological sciences},
  year={2008},
  volume={106 3},
  pages={469-77}
}
Aspirin and nonsteroidal anti-inflammatory agents are known to induce gastroduodenal complications such as ulcer, bleeding, and dyspepsia. In this study, we examined the prophylactic effect of rebamipide, an anti-ulcer agent with free-radical scavenging and anti-inflammatory effect, on acidified aspirin-induced gastric mucosal injury in rats. In addition, we investigated the mucosal barrier functions disrupted by aspirin. Oral administration of acidified aspirin resulted in linear hemorrhagic… CONTINUE READING