Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum.

@article{Okhuysen1998ProphylacticEO,
  title={Prophylactic effect of bovine anti-Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum.},
  author={Pablo C Okhuysen and Cynthia L. Chappell and J H Crabb and Luis Manuel Valdez and Edwin Douglass and H L DuPont},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1998},
  volume={26 6},
  pages={1324-9}
}
Bovine hyperimmune anti-Cryptosporidium colostrum immunoglobulin (BACI) decreases the intensity of Cryptosporidium parvum infection in vitro. We investigated the prophylactic effect of BACI in healthy adults challenged with C. parvum. After we established an oocyst dose that resulted in 100% infection in four volunteers (baseline group), 16 volunteers were randomized to receive (1) BACI prior to C. parvum challenge (BACI group) and a nonfat milk placebo 30 minutes later, (2) BACI prior to and… CONTINUE READING
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