Prophylactic cranial irradiation in extensive small-cell lung cancer.

  title={Prophylactic cranial irradiation in extensive small-cell lung cancer.},
  author={Ben J. Slotman and Corinne Faivre-Finn and Gijs W P M Kramer and Elaine Rankin and Michael P Snee and Matthew Hatton and Pieter E. Postmus and Laurence Collette and Elena Musat and Suresh Senan},
  journal={The New England journal of medicine},
  volume={357 7},
  • Ben J. Slotman, Corinne Faivre-Finn, +7 authors Suresh Senan
  • Published 2007 in The New England journal of medicine
BACKGROUND We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy. METHODS Patients between the ages of 18 and 75 years with extensive small-cell lung cancer were randomly assigned to undergo prophylactic cranial irradiation (irradiation group) or receive no further therapy (control group). The primary end point was the time to symptomatic brain metastases. Computed tomography or magnetic… CONTINUE READING
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