Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.

@article{Auprin1999ProphylacticCI,
  title={Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.},
  author={Anne Aup{\'e}rin and Roderigo Arriagada and Jean-Pierre Pignon and C{\'e}cile Le P{\'e}choux and Anna Gregor and Robyn J Stephens and Paul E. G. Kristjansen and Bruce Evan Johnson and Hiroshi Ueoka and H Wagner and Joseph Aisner},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 7},
  pages={476-84}
}
BACKGROUND Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. METHODS We analyzed individual data on 987 patients with small-cell lung cancer in complete remission who took part in seven trials that compared prophylactic cranial… CONTINUE READING
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