Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia.

@article{Halberg1992ProphylacticCI,
  title={Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia.},
  author={Francine E Halberg and Joel H. Kramer and Ida M Ki Moore and William M. Wara and Katherine K. Matthay and Arthur R Ablin},
  journal={International journal of radiation oncology, biology, physics},
  year={1992},
  volume={22 1},
  pages={13-6}
}
Prophylactic central nervous system treatment has dramatically improved the disease-free survival of children with acute lymphoblastic leukemia (ALL). Long-term neuropsychological sequelae are documented in children who received 2400 cGy prophylactic cranial irradiation. The dose was reduced to 1800 cGy. Available reports on developmental consequences, with short follow-up, have yielded inconsistent results. This study assesses radiation dose effects on cognitive function in children with… CONTINUE READING
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