Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia.

@article{Tyrrell2004ProphylacticBI,
  title={Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia.},
  author={Christopher J Tyrrell and Heather Payne and Teuvo L. J. Tammela and August Magnar Bakke and P{\"a}r Lodding and Louis Goedhals and Peter van Erps and Tom A Boon and C Kees van de Beek and S. O. Andersson and Tom H. Morris and Kevin F Staveley-O' Carroll},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={60 2},
  pages={476-83}
}
PURPOSE To evaluate the efficacy and tolerability of prophylactic breast irradiation in reducing the incidence and severity of bicalutamide-induced gynecomastia and breast pain. METHODS AND MATERIALS In all, 106 men with prostate cancer (T1b-T4/Nx/M0) and no current gynecomastia/breast pain were enrolled in this randomized, sham-controlled, double-blind, parallel-group multicenter trial. Patients received either a single dose of electron beam radiotherapy (10 Gy) or sham radiotherapy… CONTINUE READING

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