Prophylactic antiemetics in children undergoing tonsillectomy: high-dose vs low-dose ondansetron.

@article{Splinter1997ProphylacticAI,
  title={Prophylactic antiemetics in children undergoing tonsillectomy: high-dose vs low-dose ondansetron.},
  author={William M Splinter and E J Rhine},
  journal={Paediatric anaesthesia},
  year={1997},
  volume={7 2},
  pages={125-9; discussion 130}
}
This randomized, double-blind study assessed the impact of two different doses of intraoperative ondansetron on vomiting following tonsillectomy in 240 preadolescent children in a day care surgical setting. After anaesthesia was established by inhalation with N2O/ halothane or intravenously with propofol, the subjects were administered the study drug (50 or 150 micrograms.kg-1 ondansetron, maximum dose 8 mg). Anaesthesia was maintained with N2O/ halothane. The greater dose of ondansetron (150… CONTINUE READING

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