Prophylactic antibiotics in trauma: the hazards of underdosing.

@article{Ericsson1989ProphylacticAI,
  title={Prophylactic antibiotics in trauma: the hazards of underdosing.},
  author={Charles D Ericsson and R. P. Fischer and Brian J. Rowlands and Christopher Hunt and P Miller-Crotchett and Lisa A. Reed},
  journal={The Journal of trauma},
  year={1989},
  volume={29 10},
  pages={1356-61}
}
Prophylactic antibiotic regimens in trauma patients may be significantly altered by large fluid shifts and hyperdynamic physiologic responses. We prospectively studied prophylactic amikacin and clindamycin in 150 abdominal trauma patients requiring laparotomy, analyzing the effects of duration of coverage, dosing interval, and dose. No difference in… CONTINUE READING