Prophylactic antibiotics after severe trauma: more is not better.

  title={Prophylactic antibiotics after severe trauma: more is not better.},
  author={George C. Velmahos and Ashwani Jindal and Lc Chan and Effie Papoutsis Kritikos and Pantelis Vassiliu and Thomas V. Berne and Demetrios Demetriades},
  journal={International surgery},
  volume={86 3},
After severe trauma, physicians frequently use multiple antibiotics for prolonged periods of time to prevent sepsis, based on intuition rather than scientific evidence. Over a 1-year period (January-December 1999) we included prospectively 112 critically injured patients who required an operation and/or chest tube insertion and stayed for more than 2 days… CONTINUE READING