Prophylactic and therapeutic intervention in IgE responses by biolistic DNA vaccination primarily targeting dendritic cells.

@article{Sudowe2006ProphylacticAT,
  title={Prophylactic and therapeutic intervention in IgE responses by biolistic DNA vaccination primarily targeting dendritic cells.},
  author={Stephan Sudowe and Isis Ludwig-Portugall and Evelyn Montermann and R. Ross and Angelika Reske-Kunz},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={117 1},
  pages={
          196-203
        }
}
BACKGROUND Allergen gene transfer represents an alternative approach to specific immunotherapy with allergen extracts. Gene gun-mediated DNA immunization with plasmid vectors expressing a transgene under control of the promoter of the fascin gene (pFascin) allows for antigen production predominantly by dendritic cells and resulted in the generation of CD8(+) cytotoxic T lymphocytes as well as in the development of a type 1 immune response. OBJECTIVE We compared the in vivo efficiency of… CONTINUE READING
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