Prophylactic and therapeutic immune reconstitution of SCID mice infected with Encephalitozoon cuniculi.

@article{Hermnek1993ProphylacticAT,
  title={Prophylactic and therapeutic immune reconstitution of SCID mice infected with Encephalitozoon cuniculi.},
  author={Josef Herm{\'a}nek and Břetislav Koudela and Zuzana Ku{\vc}erov{\'a} and Oleg Ditrich and Jan Tr{\'a}vn{\'i}{\vc}ek},
  journal={Folia parasitologica},
  year={1993},
  volume={40 4},
  pages={287-91}
}
Severe combined immunodeficient (SCID) mice develop lethal infections, resembling opportunistic microsporidiosis of immunocompromised patients, after intraperitoneal (i.p.) inoculations of spores of Encephalitozoon cuniculi. In the present study, SCID mice reconstituted i.p. with 5 x 10(7) spleen cells from naive adult BALB/c mice 14 days prior to the i.p. injection of 10(7) spores were completely resistant to the infection, whereas control infected SCID mice developed clinical disease and died… CONTINUE READING