Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

@article{Ferguson2009ProphylacticAO,
  title={Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies},
  author={Mark W. J. Ferguson and Jonathan A L Duncan and Jeremy S. Bond and James A Bush and Piyush Durani and Karen So and Lisa D. Taylor and Jonquille Chantrey and Tracey Mason and Gaynor James and Hugh G. Laverty and Nicholas L Occleston and Abdul Sattar and Anna Ludlow and Sharon O'Kane},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={1264-1274}
}
Scar-Improving Efficacy of Avotermin Administered into the Wound Margins of Skin Incisions as Evaluated by a Randomized, Double-Blind, Placebo-Controlled, Phase II Clinical Trial
TLDR
It is confirmed that avotermin is the first of a new class of regenerative medicines that reduce scarring when administered once or twice to the approximated margins of acute skin incisions.
Avotermin for Scar Improvement following Scar Revision Surgery: A Randomized, Double-Blind, Within-Patient, Placebo-Controlled, Phase II Clinical Trial
TLDR
Avotermin administration following scar revision surgery is well tolerated and significantly improves scar appearance compared with placebo, and collagen organization in avotermin-treated scars more closely resembled normal skin in 14 of 19 cases.
The evolving role of avotermin in scar prevention
TLDR
Avotermin is a novel human recombinant TGF-β3 protein that has been studied both in vitro and in vivo for its antiscarring properties and is evaluated in a recently published Phase II clinical trial.
Safety and Efficacy of a Scar Cream Consisting of Highly Selective Growth Factors Within a Silicone Cream Matrix: A Double-Blinded, Randomized, Multicenter Study
TLDR
SKN2017B consists of highly selective growth factors within a silicone cream matrix and is well tolerated and effective for surgical scar management.
Avotermin for the improvement of scar appearance: a new pharmaceutical in a new therapeutic area
TLDR
These studies have shown that prophylactic scar improvement is pharmaceutically achievable and it is anticipated that therapeutics such as avotermin, with a sound mechanistic basis and proof of effectiveness in suitably robust clinical trials, will be available to meet the needs of patients in the foreseeable future.
Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring
TLDR
The scar improving efficacy of avotermin is confirmed which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin.
Efficacy and Tolerability of a New Pharmaceutical Form of Betamethasone Valerate in the Prevention of Hypertrophic Scars following Anterior Trunk Plastic Surgery: A Preliminary Exploratory Study
TLDR
The efficacy and tolerability of BMV plaster in the prevention of hypertrophic scar development is promising and shows a significantly greater and more rapid improvement as compared with the non-treated wounds after 4 and 8 weeks of treatment.
A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients
TLDR
Topical administration of 8% pirfenidone gel 3 times a day is more effective and safe in the treatment of hypertrophic scars caused by burns in children, as compared with standard pressure therapy.
Antiscarring pharmaceuticals: Lost in translation?
  • M. Ågren, P. Danielsen
  • Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2014
TLDR
An excellent randomized, double-blind, exploratory trial on the effect of the putative antiscarring cytokine interleukin-10 (rhIL-10; Prevascar) but the results could not be reproduced in a cohort of scarprone dark-skinned individuals in the present study.
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