Prophylactic Surgery for Multiple Endocrine Neoplasia Type IIa after Genetic Diagnosis: Is Parathyroid Transplantation Indicated?

@article{Decker1996ProphylacticSF,
  title={Prophylactic Surgery for Multiple Endocrine Neoplasia Type IIa after Genetic Diagnosis: Is Parathyroid Transplantation Indicated?},
  author={Ruth A. Decker and James D. Geiger and Charles Evandor Cox and Marilyn Mackovjak and Minakshi Sarkar and Michael L. Peacock},
  journal={World Journal of Surgery},
  year={1996},
  volume={20},
  pages={814-821}
}
RET proto-oncogene predisposing to multiple endocrine neoplasia type IIa (MEN-IIa) has allowed a DNA-based approach to diagnosis and treatment by prophylactic thyroidectomy in children testing genetically positive. Although total thyroidectomy is the accepted operation for C cell disease, the necessity of routine total parathyroidectomy and autotransplantation as previously described in these asymptomatic children is questionable, particularly given the low occurrence of hyperparathyroidism in… CONTINUE READING