Prophase microtubule arrays undergo flux-like behavior in mammalian cells.

  title={Prophase microtubule arrays undergo flux-like behavior in mammalian cells.},
  author={Nick P. Ferenz and Patricia Wadsworth},
  journal={Molecular biology of the cell},
  volume={18 10},
In higher eukaryotic cells, microtubules within metaphase and anaphase spindles undergo poleward flux, the slow, poleward movement of tubulin subunits through the spindle microtubule lattice. Although a number of studies have documented this phenomenon across a wide range of model systems, the possibility of poleward flux before nuclear envelope breakdown (NEB) has not been examined. Using a mammalian cell line expressing photoactivatable green fluorescent protein (GFP)-tubulin, we observe… CONTINUE READING
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