Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

@article{MargottinGoguet2003ProphaseDO,
  title={Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.},
  author={Florence Margottin-Goguet and Jerry Hsu and Alexander V. Loktev and Harn Mei Hsieh and Julie D. R. Reimann and Peter Kent Jackson},
  journal={Developmental cell},
  year={2003},
  volume={4 6},
  pages={813-26}
}
Progression through mitosis occurs because cyclin B/Cdc2 activation induces the anaphase promoting complex (APC) to cause cyclin B destruction and mitotic exit. To ensure that cyclin B/Cdc2 does not prematurely activate the APC in early mitosis, there must be a mechanism delaying APC activation. Emi1 is a protein capable of inhibiting the APC in S and G2. We show here that Emi1 is phosphorylated by Cdc2, and on a DSGxxS consensus site, is subsequently recognized by the SCF(betaTrCP/Slimb… CONTINUE READING
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