Property and physiological role of biliary secretory IgA in rats.

Secretory IgA (sIgA) and monomeric IgA (mIgA) were purified from normal rat bile, and their role in the gastrointestinal tract was investigated. Biliary sIgA has a molecular weight of approximately 400,000 daltons and a sedimentation constant of 11.7S. Thus, sIgA obtained from rat bile had physicochemical properties similar to those reported for sIgA in… CONTINUE READING