Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization

  title={Properties of vertebrate glutamate receptors: Calcium mobilization and desensitization},
  author={Charles F Zorumski and Liu Lin Thio},
  journal={Progress in Neurobiology},
Glutamate is now recognized as a major excitatory neurotransmitter in the vertebrate CNS, participating in a number of physiological and pathological processes. The importance of glutamate in the mobilization of intracellular Ca2+ as well as the relationship between excitatory and toxic properties has made it important to understand factors that regulate the responsivity of glutamate receptors. In recent years considerable insight has been gained about regulatory sites on NMDA receptors, with… CONTINUE READING


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