Properties of trypanothione synthetase from Trypanosoma brucei.

  title={Properties of trypanothione synthetase from Trypanosoma brucei.},
  author={Sandra L. Oza and Mark R Ariyanayagam and Niall Aitcheson and Alan H. Fairlamb},
  journal={Molecular and biochemical parasitology},
  volume={131 1},
Trypanothione [N(1),N(8)-bis(glutathionyl)spermidine] plays a central role in defence against oxidant damage, ribonucleotide metabolism and in resistance to certain drugs in trypanosomatids. In Crithidia fasciculata, synthesis of trypanothione involves sequential conjugation of two molecules of glutathione (GSH) to spermidine by two enzymes: glutathionylspermidine synthetase (GspS; EC and trypanothione synthetase (TryS; EC, whereas in Trypanosoma cruzi both steps are catalysed… CONTINUE READING


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