Properties of the voltage sensor for the opening and closing of the sodium channels in the squid giant axon

@article{Keynes1993PropertiesOT,
  title={Properties of the voltage sensor for the opening and closing of the sodium channels in the squid giant axon},
  author={Richard Darwin Keynes and Hans Meves},
  journal={Proceedings of the Royal Society of London. Series B: Biological Sciences},
  year={1993},
  volume={253},
  pages={61 - 68}
}
  • R. Keynes, H. Meves
  • Published 22 July 1993
  • Biology
  • Proceedings of the Royal Society of London. Series B: Biological Sciences
A combination of data from standard I-V curves, and from steps applied either at the initial current or in the inactivated steady state, yielded values of the total probability of the two open states of the sodium channel, multiplied by a constant scaling factor, as a function of membrane potential. The probability function PFpeak was found to reach a maximum for pulses to 40-50 mV, but for larger test potentials it underwent a slight decline. The curve for its rise was shifted in a positive… 

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