Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro.

@article{Smith1987PropertiesOT,
  title={Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro.},
  author={David J. Smith and R L Bouchal and C A deSanctis and P J Monroe and J. B. Amedro and Jeannette M. Perrotti and Terriann Crisp},
  journal={Neuropharmacology},
  year={1987},
  volume={26 9},
  pages={1253-60}
}
Analgesia induced by ketamine appears to be partially mediated by opiate mechanisms. Not only is its action attenuated by the narcotic antagonist naloxone, but the drug has a weak affinity for, and interacts stereoselectively at, opiate receptors. It also produces a classical narcotic action on the guinea-pig ileum. The present study showed that analgesic doses of the drug in rats yielded concentrations sufficient to interact effectively at opiate binding sites in vivo. A dose-dependent (80-120… CONTINUE READING

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