Properties of the O6-alkylguanine-DNA repair system of mammalian cells.

@article{Pegg1984PropertiesOT,
  title={Properties of the O6-alkylguanine-DNA repair system of mammalian cells.},
  author={Anthony E. Pegg},
  journal={IARC scientific publications},
  year={1984},
  volume={57},
  pages={575-80}
}
O6-Alkylguanine is an important lesion produced in DNA after exposure to N-nitrosodimethylamine or N-nitrosodiethylamine and may lead to mutagenesis or carcinogenesis if unrepaired. Repair of this product is accomplished by a unique DNA-repair activity which resides in a single protein. This protein catalyses the transfer of the alkyl group from the guanine O6-position to a cysteine residue. The cysteine acceptor site appears to be present on the same protein and is not regenerated. There is… CONTINUE READING