Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics

  title={Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics},
  author={John G. Wagner},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  • J. Wagner
  • Published 1 April 1973
  • Chemistry
  • Journal of Pharmacokinetics and Biopharmaceutics
Some old equations are reviewed and some new equations have been derived which indicate certain properties of the Michaelis-Menten equation and its integrated forms. Simulated data which obey Michaelis-Menten kinetics have been plotted in various ways to illustrate special relationships. An equation is derived which accurately estimates the slope of the apparently linear decline (ko)of concentrations from the values of Co, Km,and Vm.This indicates the hybrid nature of ko.It is pointed out that… 
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