Properties of the Mechanosensitive Channel MscS Pore Revealed by Tryptophan Scanning Mutagenesis

@inproceedings{Rasmussen2015PropertiesOT,
  title={Properties of the Mechanosensitive Channel MscS Pore
Revealed by Tryptophan Scanning Mutagenesis},
  author={T. S. Rasmussen and Akiko Rasmussen and Shivani Singh and Heloisa Galbiati and Michelle D. Edwards and Samantha K Miller and Ian R. Booth},
  booktitle={Biochemistry},
  year={2015}
}
Bacterial mechanosensitive channels gate when the transmembrane turgor rises to levels that compromise the structural integrity of the cell wall. Gating creates a transient large diameter pore that allows hydrated solutes to pass from the cytoplasm at rates close to those of diffusion. In the closed conformation, the channel limits transmembrane solute… CONTINUE READING