Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis.

@article{Atkin2005PropertiesOS,
  title={Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis.},
  author={Julie D. Atkin and Rachel L Scott and Jan M. West and Elizabeth C. Lopes and Alvin K J Quah and Surindar S. Cheema},
  journal={Neuromuscular disorders : NMD},
  year={2005},
  volume={15 5},
  pages={377-88}
}
This investigation was undertaken to determine if there are altered histological, pathological and contractile properties in presymptomatic or endstage diseased muscle fibres from representative slow-twitch and fast-twitch muscles of SOD1 G93A mice in comparison to wildtype mice. In presymptomatic SOD1 G93A mice, there was no detectable peripheral dysfunction, providing evidence that muscle pathology is secondary to motor neuronal dysfunction. At disease endstage however, single muscle fibre… CONTINUE READING

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