Properties of selected mutations and genotypic landscapes under Fisher's geometric model

@article{Blanquart2014PropertiesOS,
  title={Properties of selected mutations and genotypic landscapes under Fisher's geometric model},
  author={François Blanquart and Guillaume Achaz and Thomas Bataillon and Olivier Tenaillon},
  journal={Evolution},
  year={2014},
  volume={68}
}
The fitness landscape—the mapping between genotypes and fitness—determines properties of the process of adaptation. Several small genotypic fitness landscapes have recently been built by selecting a handful of beneficial mutations and measuring fitness of all combinations of these mutations. Here, we generate several testable predictions for the properties of these small genotypic landscapes under Fisher's geometric model of adaptation. When the ancestral strain is far from the fitness optimum… 

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