Properties of purified salivary ribonuclease, and salivary ribonuclease levels in children with cystic fibrosis and in heterozygous carriers.

@article{Bardon1980PropertiesOP,
  title={Properties of purified salivary ribonuclease, and salivary ribonuclease levels in children with cystic fibrosis and in heterozygous carriers.},
  author={Agn{\`e}s Bardon and David Shugar},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={1980},
  volume={101 1},
  pages={17-24}
}
Alkaline acid- and thermo-stable ribonuclease was isolated from human saliva of healthy subjects, children with cystic fibrosis, and from parents of the latter. The enzyme was purified about 180-200 times, and its ionic requirements, and specificity towards various substrates, characterized and compared with those for human pancreatic ribonuclease. The level of acid- and thermo-stable ribonuclease activity was five times higher in terms of enzyme level per ml saliva, and three times higher in… CONTINUE READING