Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers.

@article{Singh1990PropertiesOP,
  title={Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers.},
  author={Satpal Singh and Chun Fu Wu},
  journal={The Journal of experimental biology},
  year={1990},
  volume={152},
  pages={59-76}
}
The larval muscle fibers of Drosophila show four outward K+ currents in addition to the inward Ca2+ current in voltage-clamp recordings. The Shaker (Sh) and the slowpoke (slo) mutations, respectively, eliminate the voltage-activated fast K+ current (IA) and the Ca2(+)-activated fast K+ current (ICF). Quinidine specifically blocks the voltage-activated delayed K+ current (IK) at micromolar concentrations. We used Sh, slo and quinidine to remove specifically one or more K+ currents, so as to… CONTINUE READING