Properties of neuronal alpha7 mutant nicotinic acetylcholine receptors gated by bicuculline.

Abstract

We have shown previously that mutating to threonine the leucine residue in the M2 domain of the alpha7 nicotinic acetylcholine receptor (human L248T, L248T; chick L247T, L247T) converts bicuculline (BIC) from an antagonist into an agonist. In this work we studied the functional properties of the BIC-activated channels and report that, in Xenopus oocytes… (More)

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Cite this paper

@article{Tonini2003PropertiesON, title={Properties of neuronal alpha7 mutant nicotinic acetylcholine receptors gated by bicuculline.}, author={Raffaella Tonini and Eleonora Palma and Ricardo Miledi and Fabrizio Eusebi}, journal={Neuropharmacology}, year={2003}, volume={44 6}, pages={765-71} }