Properties of muscarinic acetylcholine receptors in heart cell cultures.

@article{Galper1978PropertiesOM,
  title={Properties of muscarinic acetylcholine receptors in heart cell cultures.},
  author={Jonas B. Galper and Thomas W. Smith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 12},
  pages={5831-5}
}
The binding of acetylcholine to receptors in the intact heart causes a decrease in the frequency (chronotropic effect) and force (ionotropic effect) of contraction. The studies reported here demonstrate a chronotropic response of cultured embryonic chicken heart cells to the muscarinic agonist carbamoylcholine. This response is markedly decreased after a 3… CONTINUE READING