Properties of inhibitory junctional transmission in smooth muscle of the guinea pig lower esophageal sphincter.

@article{Imaeda1998PropertiesOI,
  title={Properties of inhibitory junctional transmission in smooth muscle of the guinea pig lower esophageal sphincter.},
  author={Kenro Imaeda and Takashi Joh and Yoshimichi Yamamoto and Minoru Itoh and Hikaru Suzuki},
  journal={The Japanese journal of physiology},
  year={1998},
  volume={48 6},
  pages={457-65}
}
Inhibitory neurotransmission in guinea pig lower esophageal sphincter (LES) muscles was investigated by using electrophysiological methods. Transmural nerve stimulation (TNS) initiated an inhibitory junction potential (i.j.p.); the amplitude increased 35% by atropine (10(-6) M) and converted to a muscarinic excitatory junction potential (e.j.p.) by apamin (10(-7) M) plus Nomega-nitro-L-arginine (L-NNA, 10(-5) M). In atropinized tissue, the i.j.p. amplitude was reduced 58% by guanethidine (5 x… CONTINUE READING