Properties of human prolactin (PRL) and H27A-PRL, a mutant that does not bind Zn++.

@article{Sun1996PropertiesOH,
  title={Properties of human prolactin (PRL) and H27A-PRL, a mutant that does not bind Zn++.},
  author={Zhenyu Sun and Pakshing Li and Priscilla S. Dannies and James C. Lee},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 3},
  pages={265-71}
}
The ability of protein hormones to self-associate is likely to play an important role in concentrating hormones into secretory granules; therefore, the aggregation properties of human PRL and H27A mutant were investigated. Human PRL bound (65)Zn++; the Scatchard analysis was convex up, and limited by the solubility of PRL, but at least 0.7 mole Zn++ bound per mole of PRL. Binding of (65)Zn++ to H27A-PRL was greatly reduced. The biological activity in an Nb2 cell assay and the circular dichroism… CONTINUE READING

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