Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies
@article{Pucelik2017PropertiesOH, title={Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies}, author={Barbara Pucelik and R. Paczyński and G. Dubin and Mariette M Pereira and L. Arnaut and J. Dąbrowski}, journal={PLoS ONE}, year={2017}, volume={12} }
The impact of substituents on the photochemical and biological properties of tetraphenylporphyrin-based photosensitizers for photodynamic therapy of cancer (PDT) as well as photodynamic inactivation of microorganisms (PDI) was examined. Spectroscopic and physicochemical properties were related with therapeutic efficacy in PDT of cancer and PDI of microbial cells in vitro. Less polar halogenated, sulfonamide porphyrins were most readily taken up by cells compared to hydrophilic and anionic… CONTINUE READING
Figures, Tables, and Topics from this paper
23 Citations
Synthesis and photodynamic antimicrobial activity of amphiphilic meso-arylporphyrins with pyridyl moieties
- Chemistry
- 2020
- 1
Lipophilicity of Bacteriochlorin-Based Photosensitizers as a Determinant for PDT Optimization through the Modulation of the Inflammatory Mediators
- Medicine
- Journal of clinical medicine
- 2019
- 8
- PDF
Photoinactivation of microorganisms with sub-micromolar concentrations of imidazolium metallophthalocyanine salts.
- Chemistry, Medicine
- European journal of medicinal chemistry
- 2019
- 9
Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro
- Chemistry, Medicine
- International journal of molecular sciences
- 2020
- PDF
Enhanced Cellular Uptake and Photodynamic Effect with Amphiphilic Fluorinated Porphyrins: The Role of Sulfoester Groups and the Nature of Reactive Oxygen Species
- Chemistry, Medicine
- International journal of molecular sciences
- 2020
- 9
- PDF
Surface modification of nanocrystalline TiO_2 materials with sulfonated porphyrins for visible light antimicrobial therapy
- Chemistry
- 2019
- 5
- PDF
PEGylated Purpurin 18 with Improved Solubility: Potent Compounds for Photodynamic Therapy of Cancer
- Chemistry, Medicine
- Molecules
- 2019
- 3
- PDF
Sensitization of TiO2 by halogenated porphyrin derivatives for visible light biomedical and environmental photocatalysis
- Chemistry
- 2019
- 16
Effect of photodynamic inactivation of Escherichia coli by hypericin
- Chemistry, Medicine
- World journal of microbiology & biotechnology
- 2018
- 3
References
SHOWING 1-10 OF 62 REFERENCES
Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies
- Biology, Medicine
- Applied Microbiology and Biotechnology
- 2015
- 51
- PDF
Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers.
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2006
- 49
Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria.
- Medicine, Biology
- The Journal of antimicrobial chemotherapy
- 2002
- 233
- PDF
Fluorination of phthalocyanine substituents: Improved photoproperties and enhanced photodynamic efficacy after optimal micellar formulations.
- Chemistry, Medicine
- European journal of medicinal chemistry
- 2016
- 41
Photodynamic antimicrobial chemotherapy with the novel amino acid-porphyrin conjugate 4I: In vitro and in vivo studies
- Chemistry, Medicine
- PloS one
- 2017
- 17
Photodynamic inactivation of planktonic and biofilm growing bacteria mediated by a meso-substituted porphyrin bearing four basic amino groups.
- Biology, Medicine
- Journal of photochemistry and photobiology. B, Biology
- 2016
- 14
- PDF
Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers
- Chemistry
- 2016
- 100
Fast and Effective Photodynamic Inactivation of Multiresistant Bacteria by Cationic Riboflavin Derivatives
- Biology, Medicine
- PloS one
- 2014
- 58
- PDF
Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: role of molecular charge, central metal and hydroxyl radical production.
- Chemistry, Medicine
- Cancer letters
- 2009
- 83
5-aminolevulinic acid-mediated photodynamic therapy and its strain-dependent combined effect with antibiotics on Staphylococcus aureus biofilm
- Chemistry, Medicine
- PloS one
- 2017
- 15
- PDF