Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies

@inproceedings{Pucelik2017PropertiesOH,
  title={Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies},
  author={Barbara Pucelik and Robert Paczyński and Grzegorz Dubin and Mariette M Pereira and Luis G Arnaut and Janusz M Dąbrowski},
  booktitle={PloS one},
  year={2017}
}
The impact of substituents on the photochemical and biological properties of tetraphenylporphyrin-based photosensitizers for photodynamic therapy of cancer (PDT) as well as photodynamic inactivation of microorganisms (PDI) was examined. Spectroscopic and physicochemical properties were related with therapeutic efficacy in PDT of cancer and PDI of microbial cells in vitro. Less polar halogenated, sulfonamide porphyrins were most readily taken up by cells compared to hydrophilic and anionic… CONTINUE READING