Properties of estradiol 2-hydroxylase and 2-hydroxy-3-deoxyestradiol 3-hydroxylase in rat liver.

@article{Numazawa1979PropertiesOE,
  title={Properties of estradiol 2-hydroxylase and 2-hydroxy-3-deoxyestradiol 3-hydroxylase in rat liver.},
  author={M. Numazawa and N. Soeda and Y. Kiyono and T. Nambara},
  journal={Journal of steroid biochemistry},
  year={1979},
  volume={10 2},
  pages={
          227-33
        }
}
The properties of enzyme systems involved in the formation of catechol estrogen from estradiol and 2-hydroxy-3-deoxyestradiol in rat liver microsomes have been investigated. Molecular oxygen dissolved in the incubation medium was enough for the occurrence of 2- and 3-hydroxylations. The presence of carbon monoxide suppressed the formation of catechol estrogen from the two substrates where the CO/O2 ratios needed for 50% inhibition of the bioconversion were 12.0 and 14.1, respectively. The… Expand
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