Properties of colony-stimulating and inhibiting activities of chicken serum.

@article{Dodge1980PropertiesOC,
  title={Properties of colony-stimulating and inhibiting activities of chicken serum.},
  author={W H Dodge and Samuel H. Love and Darrell L Bryant and Reginald H. Mitchell},
  journal={Experimental hematology},
  year={1980},
  volume={8 4},
  pages={395-403}
}
Serum obtained from young chicks stimulated with endotoxin contained elevated levels of colony-stimulating activity (CSA). This CSA was partially characterized. Incubation at 65 degrees C (60 min) had no effect on the ability of the CSA to support colony formation by nonadherent cells but reduced 3-4 fold its ability to support colony formation by unfractionated marrow cells. These data suggest that most of the serum activity is due to a heat-labile, adherent cell-dependent factor which does… CONTINUE READING